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Pfizer-BioNTech COVID-19 vaccine prevents 110,000 deaths in the US

The Pfizer-BioNTech vaccine has a profound impact on the health of American citizens, ever since it was introduced on a commercial scale this year in the US. This finding has been published in the latest report of the esteemed Journal of Medical Economics.

The vaccine was introduced in the year 2021 in the US, and it became the most widely used vaccine against COVID-19 in the US. The vaccine has been successful in preventing 8.7 million cases of coronavirus. In fact, it was so effective that it prevented 690,000 cases of hospitalization and even about 110,000 deaths in the US.

The healthcare industry has been able to save more than 30 billion dollars due to this vaccine. Moreover, it has also prevented $ 40 billion in what could have been lost productivity of patients and people prone to developing coronavirus.

Pfizer-BioNTech was the first COVID-19 vaccine to have been made commercially in the US. In fact, almost six out of ten American citizens received this vaccine according to the Center for Disease Control, which is a leading public health agency in the US.

The market research study was conducted by authors who received funding from Pfizer. The authors were either employees or consultants of Pfizer. They used a real-world model to test the clinical trial data and estimate the number of cases with symptoms of COVID-19.

They also estimated the number of hospitalizations and deaths that could have occurred in the year 2021 if the vaccine had not been provided to these subjects. Moreover, they estimated the impact of these cases on the existing healthcare system and economy in general.

In the clinical trial model, the authors fed the following data: the number of people vaccinated, the efficacy of the vaccine according to different age groups, the probability of developing COVID-19, the symptoms developed, and the chances of being hospitalized.

The long-term effects of COVID-19 were also considered in the number of working days lost by the patient. The infection was classified as the leading cause of premature deaths, causing an economic burden on the country.

This research study has some limitations, which could have led to an underestimation of figures. The authors did not take into account the potential the vaccine had in reducing the transmission of COVID-19.

The severity of the cases was also not considered. Moreover, the authors did not measure the overall impact that long-standing COVID-19 cases had on the economy.  The research model did not take into account the omicron variant of the COVID-19 as it emerged much later.

 

 

 

 

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Most variants of coronavirus can be handled effectively by vaccines

 

According to researchers at the University of Yale, Moderna and Pfizer-BioNTech vaccines are the most commonly used vaccines against coronavirus. These vaccines are quite effective in combating multiple variants of SARS-CoV-2, that is, the virus that causes COVID-19. These findings were recently published in the noted medical journal Nature. Moreover, it was found that following vaccination, people infected with coronavirus showed an immune response that was more robust to all variants of coronavirus. The recent Delta variant of the virus has been reported in vaccinated people, raising doubts about the efficacy of the vaccine.

The research study found that vaccines helped the immune system fight back effectively against even new variants of the infection by inducing the production of a large number of antibodies against new variants, including the Delta. Moreover, the authors of the study urged individuals to take two doses of the vaccine. Furthermore, individuals were also requested to take booster shots to combat variants, such as Delta of the virus. The study was conducted on 40 healthcare workers from November 2020 to January 2021. This study included subjects who had not been vaccinated at the start of the study. During the course of the study, several groups of participants received two doses of the Moderna or Pfizer-BioNTech mRNA vaccines.

The blood samples of the participants were exposed to 16 different variants of SARS-COV-2 by researchers. The variants included the most powerful Delta variant, which is extensively circulating in the United States. Then, they measured the response of antibodies and T cells to all the variants. It must be noted that none of the participants were infected with the virus. In all the blood samples, the response of the immune cells was enhanced. Nevertheless, the intensity of the immune cell response depended on the variant and the participant. A robust response was noted in individuals exposed to Delta variant.

Breakthrough cases were those that showed an infection develop despite being vaccinated. These cases were caused by Delta variant but it does not mean that the vaccines failed in providing protection against coronavirus. Instead, it means that Delta variant was so infectious that it overcame the immune defense system of patient’s body. However, patients who had been vaccinated before contracting the infection showed a lesser severity in the infection. Compared to other variants, Delta is the most infectious one because it is highly transmissible. The participants were divided into groups: those who had been vaccinated before being infected with COVID-19 and those who had not been vaccinated.

The participants who had been infected before being vaccinated showed an immune response that was more robust than the participants who were not infected with the virus. The researchers were of the view that the robust immune response was like a first dose of the vaccine, recovering participants from their initial infection. The vaccinated participants should have received a booster shot, which would have increased the number of antibodies and T cells that offer protection against infections.

 

 

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Healthcare workers do not develop COVID-19 symptoms after receiving mRNA vaccine

 

In clinical practice, healthcare workers may develop symptomatic COVID-19, so they are advised to take mRNA COVID vaccines as a recent study of researchers have found them to be very effective in preventing COVID-19. The study was published in the prestigious New England Journal of Medicine.  In this study, the chances of developing symptoms of COVID-19 decreased as much as 89% in healthcare workers who received two doses of Pfizer-BioNTech vaccine. The Moderna vaccine was even more effective as it reduced the risk of developing COVID-19 by as much as 96%.

The researchers found that the vaccines were effective even in people above 50 years of age. Moreover, certain ethnic groups or racial groups who were more prone to developing COVID-19 were the ones who benefitted the most from vaccination drives. Healthcare workers who were exposed to COVID-19 patients also got immunity with vaccine. Finally, patients with underlying medical conditions benefitted from vaccines but the efficacy of the vaccine was lower in patients with compromised immunity.

The study was conducted by researchers working at the Carver College of Medicine, which is affiliated to the University of Iowa in the US. In this study, 5000 healthcare workers were evaluated: 1482 healthcare workers were found to be COVID-19 positive because they were having symptomatic illness. Moreover, 3449 healthcare workers had symptoms of COVID-19 but they were tested as negative. As many as 33 academic medical centers from the US participated in this study. The participants had to complete a survey questionnaire and provide information about their demographics, type of job, risk factors, severe disease associated with COVID-19, and the status of their vaccination.

Although all the subjects received two doses of mRNA vaccines, the risk of developing COVID-19 was reduced by 95% in Afro American subjects. On the other hand, the risk of COVID-19 declined by about 89% in Asian and Hispanic subjects and by about 94% in American Indian people. In subjects whose immunity was compromised with underlying disease, the risk of developing COVID-19 decreased by only 39%, regardless of whether they received a single dose or two doses of  mRNA vaccine. Among pregnant women who received mRNA vaccine, the risk of developing COVID-19 decreased by about 77%. Even a single dose of the vaccine was quite effective in reducing the risk of COVID-19 as compared to those unvaccinated people. The study was conducted from December 2020 to May 2021.

 

 

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The RTS,S/AS01e (RTS,S) malaria vaccine of GSK received WHO recommendation

 

The World Health Organization (WHO) has recommended GlaxoSmithKline (GSK) company’s RTS, S malaria vaccine for children who are prone to developing this disease, especially those living in sub-Sahara, African countries. It is in these countries that malaria has moderate to high high rate of transmission among children. The RTS, S is the first clinically proven vaccine that has significantly reduced the incidence of malaria in children. It took more than 30 years of intense research to develop this vaccine. The team of researchers worked at GSK and PATH companies.

GSK is working with PATH and other leading NGOs in Kenya, Malawi, and Ghana, regions with moderate to high rate of malaria transmission. In these African countries, the company is developing programs to provide easy access to RTS,S vaccine on a long term basis. For the pilot project, GSK would be donating as much as 10 million RTS,S doses and has planned to provide upto 15 million doses each year, following its widespread recommendation among the masses. Moreover, GSK is going to do technology transfer to Bharat Biotech company in India. This company would also be producing antigens on a long-term basis.

The recommendation by WHO is now considered an important milestone in the success of the vaccine RTS,S. In the August issue of New England Journal of Medicine, a key finding about the vaccine was published. The finding was based on a study conducted on 6,000 children in London, UK. The study was conducted by London School of Hygiene and Tropical Medicine. In this study, the control group received seasonal doses of antimalarial drugs under the Season Malaria Chemoprevention (SMC) program. The experimental group received SMC and RTS,S vaccine. The study was carried out for three years. The incidence of malaria and hospitalization due to malaria were reduced by as much as 70% in the experimental group.

The pilot program of Malaria vaccine was launched in the year 2019. In the three African countries of Kenya, Malawi, and Ghana, the antimalarial vaccination program was introduced successfully. These countries have moderate to high rates of transmission of malaria. More than 800,00 children were vaccinated with at least one dose. Presently, GSK team of researchers have dispersed more than 2.3 million doses of the vaccine. They have even emphasized on delivering the vaccine through the conventional immunization program for children.

 

 

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300 million doses of COVID-19 vaccine to be supplied to European Union by Sanofi and GSK

The European Union would be receiving upto 300 million doses of COVID-19 vaccine by GSK and Sanofi. Sanofi and GSK collaborated with each other to produce the vaccine candidate, which is based on recombinant protein-based technology and adjuvant technology. European countries like France, Belgium, Germany, and Italy would be manufacturing doses of this vaccine. This is a major breakthrough in fighting against COVID-19.

This is the first major vaccine against COVID-19 and it will be benefit one million Europeans, provided it is safe and effective at the clinical trial stage. The vaccine would be beneficial in tackling the global pandemic of coronavirus.

In a press release statement, the President of GSK vaccines thanked Sanofi for collaborating with them, and reiterated that the vaccine would be available soon in Europe. Both companies have worked hard to scale up operations and introduce a vaccine that will be able to tackle the growing pandemic of COVID-19.

The clinical trial would be conducted by Sanofi, and the phase 3 stage of the trial would be completed by 2020. If the vaccine produces positive results, the team of scientists at Sanofi would be filing for a regulatory approval, which is expected to be completed by the first quarter of 2021. Moreover, Sanofi and GSK have collaborated together to produce an antigen and adjuvant that would produce about one billion doses per year.

Globally, the vaccine would be available through a collaborative effort by Sanofi and GSK

In the United States and the UK, Sanofi and GSK have signed cooperation agreement with the Biomedical Advanced Research and Development Authority. The companies have decided to scale up the production of the vaccine at a global level by the end of 2021/22. The collaboration would include governments and global health organizations.

 

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Promising pilot trial for tumor vaccine

The University of Pennsylvania has conducted a promising clinical trial to devise a new type of vaccine for cancer. Although the clinical trial was of an initial stage, promising results have been meted out and researchers are hopeful of a breakthrough discovery.

The clinical trial was a joint collaboration between researchers of following medical schools, which are affiliated to the University of Pennsylvania: the Perelman School of Medicine and the Abramson Cancer Center. The vaccine is truly innovative in the sense that it corporates the immune cells of patients; the immune cells are directly exposed to the tumor cells of patients.

This experiment was carried out in a laboratory under simulated conditions. Following treatment, the immune cells are then injected into the patient to elicit a better immune response.This experimental clinical trial was performed on patients diagnosed with ovarian cancer at an advanced stage.

This was a pilot trial whose sole purpose was to determine the feasibility and safety of novel vaccine; however, the results were promising enough to ensure that is very effective in nature. Anti-tumor T-cell responses were elicited in more than half of the patients that participated in this clinical trial.

Patients that responded to this treatment had higher life expectancy despite tumor progression unlike patients who just did not elicit any response. In fact, one patient became “disease free” for five years after receiving being treated with this vaccine for two years. The promising results of this clinical trial have been published currently in the journal Science Translation Medicine.

The lead author of this study was Dr. Janos L. Tanyi, MD, who works as an assistant professor of obstetrics and gynecology at Penn Medicine. The researchers concluded that the novel vaccine was safe for clinical treatment of patients. This vaccine elicited a broad anti-tumor immunity; however, they have strongly recommended more clinical trials on a larger scale.

The other researchers who worked with the lead author at the Perelman School of Medicine at the University of Pennsylvania are as follows: Lana Kandalaft, PharmD, PhD, George Coukos, MD, PhD, and Alexandre Harari, PhD. The conventional treatment offered by cancer vaccines can be summarized as follows: A cell-surface receptor is a specific molecule that is mostly attacked by most cancer vaccines till date.

This molecule is generally found on cancerous cells in any kind of tumor. However, the team headed by Lausanne-Penn devised a far more aggressive approach. They developed a personalized vaccine that took into considered every individual cancer patients’ condition. For this purpose, they comprehensively analyzed the tumor system of each cancer patient.

The set of mutations are unique to each tumor, presenting a unique pathology of the impaired immune system. With this information, they developed a whole-tumor vaccine that elicited immune response and combated not just a single target in the tumor, but about hundreds or thousands. This is a truly innovative strategy that outshines the efficacy of conventional vaccines.

The basic objective of this clinical trial was to elicit a strong immune response that targets tumors comprehensively. They were successful in eliciting an immune response that hits all kinds of markers, including the markers that are unique to a particular tumor.

The formidable defenses of tumors were overcome by harnessing the T-cell immunity with the vaccine. To prepare a personalized vaccine for each patient, the researchers sifted through the mononuclear cells of peripheral blood, which was obtained from each patient.

They identified precursor cells that were suitable enough for use in this clinical experiment. These cells were grown into a culture in a laboratory under carefully controlled conditions. Thus, they produced a large number of dendritic cells. A T-cell immune response can be effectively elicited with the use of dendritic cells.

Infectious pathogens are engulfed by these T-cells; moreover, these T-cells also engulf tumor cells and anything that is considered “foreign”. Nevertheless, a specific response is elicited by the patients’ immune system when T-cells and other components of the immune system are again exposed to pieces of invader cells.

The patients’ tumor cells were obtained and a special extract was prepared from these tumor cells. Then, the extract of tumor cells was exposed to dendritic cells; the dendritic cells were activated by irradiating them with interferon gamma. Finally, the patients’ lymph nodes were injected with these activated dendritic cells and a T-cell response was generated.

The team of researchers successfully carried out this strategy on 25 patients in total. Every three weeks, each patient was administered a dose of dendritic cells; it is important to note that these dendritic cells were treated with tumor cells by a process described above.

The exposure of dendritic cells at periodic intervals was carried out for six months. A huge increase in the number of T-cells was reported in more than half of the patients included in this trial. What’s more fascinating is the fact that generated T-cells were specifically reactive to tumor cells. In other words, the personalized vaccine developed for combating cancer was hugely successful.

The patients that responded to this treatment showed 100 percent survival for a period of two years. The patients that failed to respond to this treatment showed an overall survival rate of just 25 percent over a two-year period.

In this experiment, researchers had a included a stage 4 ovarian cancer patient who was 46 years old. The prognosis of this patient is generally very poor with conventional treatment, which includes five courses of chemotherapy. Interestingly, this patient remained disease-free for five long years after receiving 28 doses of the personalized vaccine over a two year period.

In conclusion, the researchers hope that the efficacy of this personalized vaccine would be doubled if it is combined with chemotherapeutic drugs that strive to suppress anti-immune responses of the tumor.